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gulation in the Presence of Nutlin-3a It truly is properly established that NF-kB plays a major part in TNF-amediated survival. Moreover, the partnership among p53, TNF-a and NF-kB has been analyzed in MCF-7 breast cancer cells. In this model, TNF-a was able to induce transcription of p21 and accumulate inactive p53, but inhibition with the NF-kB pathway abrogated p21 transcription. Therefore, we